Potentially Curative Therapeutic Activity of NEO212, a Perillyl Alcohol-Temozolomide Conjugate, in Preclinical Cytarabine-Resistant Models of Acute Myeloid Leukemia

Potentially Curative Therapeutic Activity of NEO212, a Perillyl Alcohol-Temozolomide Conjugate, in Preclinical Cytarabine-Resistant Models of Acute Myeloid Leukemia

Despite progress in the treatment of acute myeloid leukemia (AML), the clinical outcome remains suboptimal and many patients are still dying from this disease. First-line treatment consists of chemotherapy, which typically includes cytarabine (AraC), either alone or in combination with anthracycline...

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Bibliographic Details
Main Authors: Axel H. Schönthal, Steve Swenson, Radu O. Minea, Hye Na Kim, Heeyeon Cho, Nazleen Mohseni, Yong-Mi Kim, Thomas C. Chen
Format: Article
Language:English
Published: MDPI AG 2021-07-01
Series:Cancers
Subjects:
cytarabine resistance
DNA alkylation
acute myeloid leukemia
perillyl alcohol
Online Access:https://www.mdpi.com/2072-6694/13/14/3385

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https://www.mdpi.com/2072-6694/13/14/3385

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