Strategies for the expansion of human induced pluripotent stem cells as aggregates in single-use Vertical-Wheel™ bioreactors

Strategies for the expansion of human induced pluripotent stem cells as aggregates in single-use Vertical-Wheel™ bioreactors

Abstract Background Since their inception, human induced pluripotent stem cells (hiPSCs) have held much promise for pharmacological applications and cell-based therapies. However, their potential can only be realised if large numbers of cells can be produced reproducibly on-demand. While bioreactors...

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Bibliographic Details
Main Authors: Diogo E. S. Nogueira, Carlos A. V. Rodrigues, Marta S. Carvalho, Cláudia C. Miranda, Yas Hashimura, Sunghoon Jung, Brian Lee, Joaquim M. S. Cabral
Format: Article
Language:English
Published: BMC 2019-09-01
Series:Journal of Biological Engineering
Subjects:
Human induced pluripotent stem cells
Expansion
Aggregates
Fed-batch
Dextran sulfate
Single-use bioreactors
Online Access:http://link.springer.com/article/10.1186/s13036-019-0204-1

Internet

http://link.springer.com/article/10.1186/s13036-019-0204-1

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