Phosphoinositol 3-kinase-driven NET formation involves different isoforms and signaling partners depending on the stimulus

Phosphoinositol 3-kinase-driven NET formation involves different isoforms and signaling partners depending on the stimulus

Neutrophil extracellular traps (NETs) serve to immobilize and kill pathogens, but also can contribute to the progression of several inflammatory and auto-immune diseases, as well as cancer. Whence the importance of elucidating the mechanisms underlying NET formation. In this regard, the PI3K signali...

Full description

Bibliographic Details
Main Authors: Vanessa de Carvalho Oliveira, Olga Tatsiy, Patrick P. McDonald
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-01-01
Series:Frontiers in Immunology
Subjects:
neutrophil extracellular traps
PI 3-kinase
PDK1
mTOR
PLCγ2
Akt
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1042686/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2023.1042686/full

Similar Items