A neurochemical closed-loop controller for deep brain stimulation: toward individualized smart neuromodulation therapies.

A neurochemical closed-loop controller for deep brain stimulation: toward individualized smart neuromodulation therapies.

Current strategies for optimizing deep brain stimulation (DBS) therapy involve multiple postoperative visits. During each visit, stimulation parameters are adjusted until desired therapeutic effects are achieved and adverse effects are minimized. However, the efficacy of these therapeutic parameters...

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Bibliographic Details
Main Authors: Peter Jonas Grahn, Grant W. Mallory, Obaid U. Khurram, Brent M. Berry, Jan T. Hachmann, Allan J Bieber, Kevin E Bennet, Paul H. Min, Su-youne eChang, Kendall H Lee, J Luis Lujan
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-06-01
Series:Frontiers in Neuroscience
Subjects:
Individualized Medicine
machine learning
deep brain stimulation (DBS)
fast scan cyclic voltammetry
local field potential (LFP)
feedback control systems
Online Access:http://journal.frontiersin.org/Journal/10.3389/fnins.2014.00169/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fnins.2014.00169/full

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