The Calcium-Induced Regulation in the Molecular and Transcriptional Circuitry of Human Inflammatory Response and Autoimmunity

The Calcium-Induced Regulation in the Molecular and Transcriptional Circuitry of Human Inflammatory Response and Autoimmunity

Rheumatoid arthritis synovial fibroblasts (RASFs) are fundamental effector cells in RA driving the joint inflammation and deformities. Celastrol is a natural compound that exhibits a potent anti-arthritic effect promoting endoplasmic reticulum (ER) stress mediated by intracellular calcium (Ca2+) mob...

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Bibliographic Details
Main Authors: Ivo R. de Seabra Rodrigues Dias, Simon W. F. Mok, Flora Gordillo-Martínez, Imran Khan, Wendy W. L. Hsiao, Betty Y. K. Law, Vincent K. W. Wong, Liang Liu
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-01-01
Series:Frontiers in Pharmacology
Subjects:
Rheumatoid arthritis
RASFs
celastrol
calcium
inflammation
autoimmunity
Online Access:http://journal.frontiersin.org/article/10.3389/fphar.2017.00962/full

Internet

http://journal.frontiersin.org/article/10.3389/fphar.2017.00962/full

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