A proteomics approach for the identification of cullin-9 (CUL9) related signaling pathways in induced pluripotent stem cell models.

CUL9 is a non-canonical and poorly characterized member of the largest family of E3 ubiquitin ligases known as the Cullin RING ligases (CRLs). Most CRLs play a critical role in developmental processes, however, the role of CUL9 in neuronal development remains elusive. We determined that deletion or...

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Bibliographic Details
Main Authors: Natalya A Ortolano, Alejandra I Romero-Morales, Megan L Rasmussen, Caroline Bodnya, Leigh A Kline, Piyush Joshi, Jon P Connelly, Kristie L Rose, Shondra M Pruett-Miller, Vivian Gama
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2021-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0248000