Characterization of disease-propagating stem cells responsible for myeloproliferative neoplasm–blast phase

Characterization of disease-propagating stem cells responsible for myeloproliferative neoplasm–blast phase

Chronic myeloproliferative neoplasms (MPN) frequently evolve to a blast phase (BP) that is almost uniformly resistant to induction chemotherapy or hypomethylating agents. We explored the functional properties, genomic architecture, and cell of origin of MPN-BP initiating cells (IC) using a serial NS...

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Bibliographic Details
Main Authors: Xiaoli Wang, Raajit K. Rampal, Cing Siang Hu, Joseph Tripodi, Noushin Farnoud, Bruce Petersen, Michael R. Rossi, Minal Patel, Erin McGovern, Vesna Najfeld, Camelia Iancu-Rubin, Min Lu, Andrew Davis, Marina Kremyanskaya, Rona Singer Weinberg, John Mascarenhas, Ronald Hoffman
Format: Article
Language:English
Published: American Society for Clinical investigation 2022-04-01
Series:JCI Insight
Subjects:
Oncology
Stem cells
Online Access:https://doi.org/10.1172/jci.insight.156534

Internet

https://doi.org/10.1172/jci.insight.156534

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