Multivariate generalized mixed-effects models for screening multiple adverse drug reactions in spontaneous reporting systems

Introduction: For assessing drug safety using spontaneous reporting system databases, quantitative measurements, such as proportional reporting rate (PRR) and reporting odds ratio (ROR), are widely employed to assess the relationship between a drug and a suspected adverse drug reaction (ADR). The da...

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Bibliographic Details
Main Authors: Masahiko Gosho, Ryota Ishii, Tomohiro Ohigashi, Kazushi Maruo
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-01-01
Series:Frontiers in Pharmacology
Subjects:
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2024.1312803/full