A New Phenylpyrazoleanilide, Y-320, Inhibits Interleukin 17 Production and Ameliorates Collagen-Induced Arthritis in Mice and Cynomolgus Monkeys

A New Phenylpyrazoleanilide, Y-320, Inhibits Interleukin 17 Production and Ameliorates Collagen-Induced Arthritis in Mice and Cynomolgus Monkeys

Interleukin (IL)-15 and IL-17 are thought to play an important role in the pathogenesis of rheumatoid arthritis (RA) because both pro-inflammatory cytokines are found in synovial fluid of RA patients. In this study, we examined the pharmacological profiles of Y-320, a new phenylpyrazoleanilide immun...

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Bibliographic Details
Main Authors: Hiroyuki Ushio, Seigo Ishibuchi, Koichi Oshita, Noriyasu Seki, Hirotoshi Kataoka, Kunio Sugahara, Kunitomo Adachi, Kenji Chiba
Format: Article
Language:English
Published: MDPI AG 2013-12-01
Series:Pharmaceuticals
Subjects:
interleukin 15 (IL-15)
interleukin 17 (IL-17)
phenylpyrazoleanilide
Y-320
immunomodulator
collagen-induced arthritis (CIA)
rheumatoid arthritis (RA)
Online Access:http://www.mdpi.com/1424-8247/7/1/1

Internet

http://www.mdpi.com/1424-8247/7/1/1

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