Next-Generation CEA-CAR-NK-92 Cells against Solid Tumors: Overcoming Tumor Microenvironment Challenges in Colorectal Cancer

Next-Generation CEA-CAR-NK-92 Cells against Solid Tumors: Overcoming Tumor Microenvironment Challenges in Colorectal Cancer

Colorectal carcinoma (CRC) presents a formidable medical challenge, demanding innovative therapeutic strategies. Chimeric antigen receptor (CAR) natural killer (NK) cell therapy has emerged as a promising alternative to CAR T-cell therapy for cancer. A suitable tumor antigen target on CRC is carcino...

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Bibliographic Details
Main Authors: Alexander Sebastian Franzén, Abdelhadi Boulifa, Clarissa Radecke, Sebastian Stintzing, Martin J. Raftery, Gabriele Pecher
Format: Article
Language:English
Published: MDPI AG 2024-01-01
Series:Cancers
Subjects:
immunotherapy
CAR-NK
CEA
PD1-checkpoint inhibition (CPI)
CCR4
colorectal carcinoma (CRC)
Online Access:https://www.mdpi.com/2072-6694/16/2/388

Internet

https://www.mdpi.com/2072-6694/16/2/388

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