Hydroxy-α-sanshool isolated from Zanthoxylum bungeanum Maxim. has antidiabetic effects on high-fat-fed and streptozotocin-treated mice via increasing glycogen synthesis by regulation of PI3K/Akt/GSK-3β/GS signaling

Hydroxy-α-sanshool isolated from Zanthoxylum bungeanum Maxim. has antidiabetic effects on high-fat-fed and streptozotocin-treated mice via increasing glycogen synthesis by regulation of PI3K/Akt/GSK-3β/GS signaling

Type 2 diabetes mellitus (T2DM) is a chronic metabolic disease characterized by hyperglycemia. The fruits of Zanthoxylum bungeanum Maxim. is a common spice and herbal medicine in China, and hydroxy-α-sanshool (HAS) is the most abundant amide in Z. bungeanum and reported to have significant hypoglyce...

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Bibliographic Details
Main Authors: Qing Zhang, Ruo-Lan Li, Ling-Yu Wang, Ting Zhang, Die Qian, Dan-Dan Tang, Cheng-Xun He, Chun-Jie Wu, Li Ai
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-12-01
Series:Frontiers in Pharmacology
Subjects:
type 2 diabetes mellitus
hydroxy-α-sanshool
Zanthoxylum bungeanum Maxim.
glycogen synthesis
PI3K/Akt/GSK-3β pathway
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.1089558/full

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https://www.frontiersin.org/articles/10.3389/fphar.2022.1089558/full

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