A mouse model for X-linked Alport syndrome induced by Del-ATGG in the Col4a5 gene

A mouse model for X-linked Alport syndrome induced by Del-ATGG in the Col4a5 gene

Alport syndrome (AS) is an inherited glomerular basement membrane (GBM) disease leading to end-stage renal disease (ESRD). X-linked AS (XLAS) is caused by pathogenic variants in the COL4A5 gene. Many pathogenic variants causing AS have been detected, but the genetic modifications and pathological al...

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Bibliographic Details
Main Authors: Wei-qing Wu, Jia-xun Zhang, Ying-xia Cui, Ming-chao Zhang, Xiao-hang Chen, Shan Duan, Cai-hong Zeng, Pei-ning Li, Xiao-jun Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-03-01
Series:Frontiers in Medicine
Subjects:
X-linked Alport syndrome
mouse model
Col4a5 gene
frameshift variant
RNA-sequencing
Online Access:https://www.frontiersin.org/articles/10.3389/fmed.2023.1086756/full

Internet

https://www.frontiersin.org/articles/10.3389/fmed.2023.1086756/full

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