Mild hyperthermia via gold nanoparticles and visible light irradiation for enhanced siRNA and ASO delivery in 2D and 3D tumour spheroids

Mild hyperthermia via gold nanoparticles and visible light irradiation for enhanced siRNA and ASO delivery in 2D and 3D tumour spheroids

Abstract Background The delivery of therapeutic nucleic acids, such as small interfering RNA (siRNA) and antisense oligonucleotides (ASO) into cells, is widely used in gene therapy. Gold nanoparticles (AuNPs) have proved to be effective in delivering silencing moieties with high efficacy. Moreover,...

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Bibliographic Details
Main Authors: Daniela Ferreira, Alexandra R. Fernandes, Pedro V. Baptista
Format: Article
Language:English
Published: BMC 2024-03-01
Series:Cancer Nanotechnology
Subjects:
Mild hyperthermy
Gold nanoparticles
Gene silencing
Laser irradiation
Therapeutic nucleic acids transfection
3D tumour spheroids
Online Access:https://doi.org/10.1186/s12645-024-00256-4

Internet

https://doi.org/10.1186/s12645-024-00256-4

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