Identification of Multicolor Fluorescent Probes for Heterogeneous Aβ Deposits in Alzheimer’s Disease

Identification of Multicolor Fluorescent Probes for Heterogeneous Aβ Deposits in Alzheimer’s Disease

Accumulation of amyloid-beta (Aβ) into amyloid plaques and hyperphosphorylated tau into neurofibrillary tangles (NFTs) are pathological hallmarks of Alzheimer’s disease (AD). There is a significant intra- and inter-individual variability in the morphology and conformation of Aβ aggregates, which may...

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Bibliographic Details
Main Authors: Abhisek Mukherjee, Rabab Al-Lahham, Mark E. Corkins, Sourav Samanta, Ann M. Schmeichel, Wolfgang Singer, Phillip A. Low, Thimmaiah Govindaraju, Claudio Soto
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-02-01
Series:Frontiers in Aging Neuroscience
Subjects:
Alzheimer’s disease
Aβ plaques
neuritic plaques
neurofibrillary tangles
Lewy bodies
amyloid plaque heterogeneity
Online Access:https://www.frontiersin.org/articles/10.3389/fnagi.2021.802614/full

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https://www.frontiersin.org/articles/10.3389/fnagi.2021.802614/full

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