Synthetic biology and microbioreactor platforms for programmable production of biologics at the point-of-care

Current biopharmaceutical manufacturing platforms use single biologic-producing cell lines cultured at large scales. Here the authors develop a small-scale, portable biomanufacturing platform to produce single dose IFNa2b and rHGH from a single engineered strain of P. pastoris.

Bibliographic Details
Main Authors: Pablo Perez-Pinera, Ningren Han, Sara Cleto, Jicong Cao, Oliver Purcell, Kartik A. Shah, Kevin Lee, Rajeev Ram, Timothy K. Lu
Format: Article
Language:English
Published: Nature Portfolio 2016-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/ncomms12211