Synthetic biology and microbioreactor platforms for programmable production of biologics at the point-of-care
Current biopharmaceutical manufacturing platforms use single biologic-producing cell lines cultured at large scales. Here the authors develop a small-scale, portable biomanufacturing platform to produce single dose IFNa2b and rHGH from a single engineered strain of P. pastoris.
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2016-07-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/ncomms12211 |
| _version_ | 1828958823336902656 |
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| author | Pablo Perez-Pinera Ningren Han Sara Cleto Jicong Cao Oliver Purcell Kartik A. Shah Kevin Lee Rajeev Ram Timothy K. Lu |
| author_facet | Pablo Perez-Pinera Ningren Han Sara Cleto Jicong Cao Oliver Purcell Kartik A. Shah Kevin Lee Rajeev Ram Timothy K. Lu |
| author_sort | Pablo Perez-Pinera |
| collection | DOAJ |
| description | Current biopharmaceutical manufacturing platforms use single biologic-producing cell lines cultured at large scales. Here the authors develop a small-scale, portable biomanufacturing platform to produce single dose IFNa2b and rHGH from a single engineered strain of P. pastoris. |
| first_indexed | 2024-12-14T08:55:46Z |
| format | Article |
| id | doaj.art-7d4eb34812f54fcf8365ae570daf603d |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-14T08:55:46Z |
| publishDate | 2016-07-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-7d4eb34812f54fcf8365ae570daf603d2022-12-21T23:08:56ZengNature PortfolioNature Communications2041-17232016-07-017111010.1038/ncomms12211Synthetic biology and microbioreactor platforms for programmable production of biologics at the point-of-carePablo Perez-Pinera0Ningren Han1Sara Cleto2Jicong Cao3Oliver Purcell4Kartik A. Shah5Kevin Lee6Rajeev Ram7Timothy K. Lu8Department of Biological Engineering and Electrical Engineering & Computer Science, Synthetic Biology Group, Massachusetts Institute of TechnologyResearch Laboratory of Electronics, Massachusetts Institute of TechnologyDepartment of Biological Engineering and Electrical Engineering & Computer Science, Synthetic Biology Group, Massachusetts Institute of TechnologyDepartment of Biological Engineering and Electrical Engineering & Computer Science, Synthetic Biology Group, Massachusetts Institute of TechnologyDepartment of Biological Engineering and Electrical Engineering & Computer Science, Synthetic Biology Group, Massachusetts Institute of TechnologyThe David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of TechnologyPharyx Inc.Research Laboratory of Electronics, Massachusetts Institute of TechnologyDepartment of Biological Engineering and Electrical Engineering & Computer Science, Synthetic Biology Group, Massachusetts Institute of TechnologyCurrent biopharmaceutical manufacturing platforms use single biologic-producing cell lines cultured at large scales. Here the authors develop a small-scale, portable biomanufacturing platform to produce single dose IFNa2b and rHGH from a single engineered strain of P. pastoris.https://doi.org/10.1038/ncomms12211 |
| spellingShingle | Pablo Perez-Pinera Ningren Han Sara Cleto Jicong Cao Oliver Purcell Kartik A. Shah Kevin Lee Rajeev Ram Timothy K. Lu Synthetic biology and microbioreactor platforms for programmable production of biologics at the point-of-care Nature Communications |
| title | Synthetic biology and microbioreactor platforms for programmable production of biologics at the point-of-care |
| title_full | Synthetic biology and microbioreactor platforms for programmable production of biologics at the point-of-care |
| title_fullStr | Synthetic biology and microbioreactor platforms for programmable production of biologics at the point-of-care |
| title_full_unstemmed | Synthetic biology and microbioreactor platforms for programmable production of biologics at the point-of-care |
| title_short | Synthetic biology and microbioreactor platforms for programmable production of biologics at the point-of-care |
| title_sort | synthetic biology and microbioreactor platforms for programmable production of biologics at the point of care |
| url | https://doi.org/10.1038/ncomms12211 |
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