Synthetic biology and microbioreactor platforms for programmable production of biologics at the point-of-care
Current biopharmaceutical manufacturing platforms use single biologic-producing cell lines cultured at large scales. Here the authors develop a small-scale, portable biomanufacturing platform to produce single dose IFNa2b and rHGH from a single engineered strain of P. pastoris.
Main Authors: | Pablo Perez-Pinera, Ningren Han, Sara Cleto, Jicong Cao, Oliver Purcell, Kartik A. Shah, Kevin Lee, Rajeev Ram, Timothy K. Lu |
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Format: | Article |
Language: | English |
Published: |
Nature Portfolio
2016-07-01
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Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/ncomms12211 |
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