Automated vitrification of cryo-EM samples with controllable sample thickness using suction and real-time optical inspection

Automated vitrification of cryo-EM samples with controllable sample thickness using suction and real-time optical inspection

Faster cryo specimen preparation can advance cryo electron microscopy (cryoEM). Here, the authors present a vitrification device with automated sample handling for cryoEM of proteins, suspensions and cells, enabling blot-free sample thinning, dew-point control and characterization of cryo grids prio...

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Bibliographic Details
Main Authors: Roman I. Koning, Hildo Vader, Martijn van Nugteren, Peter A. Grocutt, Wen Yang, Ludovic L. R. Renault, Abraham J. Koster, Arnold C. F. Kamp, Michael Schwertner
Format: Article
Language:English
Published: Nature Portfolio 2022-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-022-30562-7

Internet

https://doi.org/10.1038/s41467-022-30562-7

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