Automated vitrification of cryo-EM samples with controllable sample thickness using suction and real-time optical inspection
Faster cryo specimen preparation can advance cryo electron microscopy (cryoEM). Here, the authors present a vitrification device with automated sample handling for cryoEM of proteins, suspensions and cells, enabling blot-free sample thinning, dew-point control and characterization of cryo grids prio...
Main Authors: | , , , , , , , , |
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Format: | Article |
Language: | English |
Published: |
Nature Portfolio
2022-05-01
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Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/s41467-022-30562-7 |