Abl Tyrosine Kinase Regulates Hepatitis C Virus Entry

Abl Tyrosine Kinase Regulates Hepatitis C Virus Entry

Abl is a central regulator of multiple cellular processes controlling actin dynamics, proliferation, and differentiation. Here, we showed that knockdown of Abl impaired hepatitis C virus (HCV) propagation. Treatment of Abl tyrosine kinase-specific inhibitor, imatinib and dasatinib, also significantl...

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Bibliographic Details
Main Authors: Saehong Min, Yun-Sook Lim, Dongjo Shin, Chorong Park, Jae-Bong Park, Seungtaek Kim, Marc P. Windisch, Soon B. Hwang
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-06-01
Series:Frontiers in Microbiology
Subjects:
hepatitis C virus
Abl tyrosine kinase
host factor
HCV entry
tyrosine kinase- inhibitor
viral propagation
Online Access:http://journal.frontiersin.org/article/10.3389/fmicb.2017.01129/full

Internet

http://journal.frontiersin.org/article/10.3389/fmicb.2017.01129/full

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