G-Quadruplexes Formation by the <i>C9orf72</i> Nucleotide Repeat Expansion d(GGGGCC)<sub>n</sub> and Conformation Regulation by Fangchinoline

G-Quadruplexes Formation by the <i>C9orf72</i> Nucleotide Repeat Expansion d(GGGGCC)<sub>n</sub> and Conformation Regulation by Fangchinoline

The G-quadruplex (GQ)-forming hexanucleotide repeat expansion (HRE) in the <i>C9orf72</i> (C9) gene has been found to be the most common cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) (collectively, C9ALS/FTD), implying the great significance of modulating...

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Bibliographic Details
Main Authors: Yun Zhang, Junliu Huang, Kainan Yu, Xiaojie Cui
Format: Article
Language:English
Published: MDPI AG 2023-06-01
Series:Molecules
Subjects:
G-quadruplex
<i>C9orf72</i> hexanucleotide repeat
Fangchinoline
Online Access:https://www.mdpi.com/1420-3049/28/12/4671

Internet

https://www.mdpi.com/1420-3049/28/12/4671

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