Germline mutations in penetrant cancer predisposition genes are rare in men with prostate cancer selecting active surveillance

Germline mutations in penetrant cancer predisposition genes are rare in men with prostate cancer selecting active surveillance

Abstract Background Pathogenic germline mutations in several rare penetrant cancer predisposition genes are associated with an increased risk of aggressive prostate cancer (PC). Our objectives were to determine the prevalence of pathogenic germline mutations in men with low‐risk PC on active surveil...

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Bibliographic Details
Main Authors: Lauren Brady, Lisa F. Newcomb, Kehao Zhu, Yingye Zheng, Hilary Boyer, Navonil De Sarkar, Jesse K. McKenney, James D. Brooks, Peter R. Carroll, Atreya Dash, William J. Ellis, Christopher P. Filson, Martin E. Gleave, Michael A. Liss, Frances Martin, Todd M. Morgan, Ian M. Thompson, Andrew A. Wagner, Colin C. Pritchard, Daniel W. Lin, Peter S. Nelson
Format: Article
Language:English
Published: Wiley 2022-11-01
Series:Cancer Medicine
Subjects:
active surveillance
adverse pathology
germline mutations
prostate cancer
Online Access:https://doi.org/10.1002/cam4.4778

Internet

https://doi.org/10.1002/cam4.4778

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