Enduring disruption of reward and stress circuit activities by early-life adversity in male rats

Abstract In humans, early-life adversity (ELA) such as trauma, poverty, and chaotic environment is linked to increased risk of later-life emotional disorders including depression and substance abuse. These disorders involve underlying disruption of reward circuits and likely vary by sex. Accordingly...

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Bibliographic Details
Main Authors: Sophia C. Levis, Matthew T. Birnie, Jessica L. Bolton, Christina R. Perrone, Johanna S. Montesinos, Tallie Z. Baram, Stephen V. Mahler
Format: Article
Language:English
Published: Nature Publishing Group 2022-06-01
Series:Translational Psychiatry
Online Access:https://doi.org/10.1038/s41398-022-01988-w