The MDM2-p53 pathway is involved in preconditioning-induced neuronal tolerance to ischemia

Abstract Brain preconditioning (PC) refers to a state of transient tolerance against a lethal insult that can be evoked by a prior mild event. It is thought that PC may induce different pathways responsible for neuroprotection, which may involve the attenuation of cell damage pathways, including the...

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Bibliographic Details
Main Authors: Rebeca Vecino, Maria C. Burguete, Teresa Jover-Mengual, Jesus Agulla, Verónica Bobo-Jiménez, Juan B. Salom, Angeles Almeida, Maria Delgado-Esteban
Format: Article
Language:English
Published: Nature Portfolio 2018-01-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-018-19921-x