A model-based approach for a practical dosing strategy for the short, intensive treatment regimen for paediatric tuberculous meningitis

A model-based approach for a practical dosing strategy for the short, intensive treatment regimen for paediatric tuberculous meningitis

Following infection with Mycobacterium tuberculosis, young children are at high risk of developing severe forms of tuberculosis (TB) disease, including TB meningitis (TBM), which is associated with significant morbidity and mortality. In 2022, the World Health Organization (WHO) conditionally recomm...

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Bibliographic Details
Main Authors: Roeland E. Wasmann, Tiziana Masini, Kerri Viney, Sabine Verkuijl, Annemieke Brands, Anneke C. Hesseling, Helen McIlleron, Paolo Denti, Kelly E. Dooley
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-04-01
Series:Frontiers in Pharmacology
Subjects:
WHO
NONMEM
paediatric dosing
rifampicin
rifampin
isoniazid
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2023.1055329/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2023.1055329/full

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