Inhibition of Hedgehog signaling reprograms the dysfunctional immune microenvironment in breast cancer

Inhibition of Hedgehog signaling reprograms the dysfunctional immune microenvironment in breast cancer

Host responses to tumor cells include tumor suppressing or promoting mechanisms. We sought to detail the effect of Hedgehog (Hh) pathway inhibition on the composition of the mammary tumor immune portfolio. We hypothesized that Hh signaling mediates a crosstalk between breast cancer cells and macroph...

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Bibliographic Details
Main Authors: Ann Hanna, Brandon J. Metge, Sarah K. Bailey, Dongquan Chen, Darshan S. Chandrashekar, Sooryanarayana Varambally, Rajeev S. Samant, Lalita A. Shevde
Format: Article
Language:English
Published: Taylor & Francis Group 2019-03-01
Series:OncoImmunology
Subjects:
breast cancer
hedgehog signaling
tumor microenvironment
tumor associated macrophages
metastasis
Online Access:http://dx.doi.org/10.1080/2162402X.2018.1548241

Internet

http://dx.doi.org/10.1080/2162402X.2018.1548241

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