BRET and Time-resolved FRET strategy to study GPCR oligomerization: from cell lines toward native tissues

BRET and Time-resolved FRET strategy to study GPCR oligomerization: from cell lines toward native tissues

The concept of oligomerization of G protein-coupled receptor (GPCR) opens new perspectives regarding physiological function regulation. The capacity of one GPCR to modify its binding and coupling properties by interacting with a second one can be at the origin of regulations unsuspected two decades...

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Bibliographic Details
Main Authors: Martin eCottet, Orestis eFaklaris, Damien eMaurel, Pauline eScholler, Etienne eDoumazane, Eric eTrinquet, Jean-Philippe R Pin, Thierry eDURROUX
Format: Article
Language:English
Published: Frontiers Media S.A. 2012-07-01
Series:Frontiers in Endocrinology
Subjects:
Terbium
Oligomerization
dimerization
fluorescent ligand
G protein-coupled receptor
native tissue
Online Access:http://journal.frontiersin.org/Journal/10.3389/fendo.2012.00092/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fendo.2012.00092/full

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