Pyrroloquinoline quinone promotes human mesenchymal stem cell-derived mitochondria to improve premature ovarian insufficiency in mice through the SIRT1/ATM/p53 pathway

Pyrroloquinoline quinone promotes human mesenchymal stem cell-derived mitochondria to improve premature ovarian insufficiency in mice through the SIRT1/ATM/p53 pathway

Abstract Background DNA damage and oxidative stress induced by chemotherapy are important factors in the onset of premature ovarian insufficiency (POI). Studies have shown that mitochondria derived from mesenchymal stem cells (MSC-Mito) are beneficial for age-related diseases, but their efficacy alo...

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Bibliographic Details
Main Authors: Shengjie Liu, Yuanmei Wang, Hanlin Yang, Jun Tan, Jingkaiwen Zhang, Dan Zi
Format: Article
Language:English
Published: BMC 2024-04-01
Series:Stem Cell Research & Therapy
Subjects:
Premature ovarian insufficiency
DNA damage
Oxidative stress
Mesenchymal stem cells
Pyrroloquinoline quinone
Mitochondrial transplantation
Online Access:https://doi.org/10.1186/s13287-024-03705-4

Internet

https://doi.org/10.1186/s13287-024-03705-4

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