Antigen-specific B cells reactivate an effective cytotoxic T cell response against phagocytosed Salmonella through cross-presentation.

BACKGROUND: The eradication of facultative intracellular bacterial pathogens, like Salmonella typhi, requires the concerted action of both the humoral immune response and the cytotoxic CD8(+) T cell response. Dendritic cells (DCs) are considered to orchestrate the cytotoxic CD8(+) T cell response vi...

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Hlavní autoři: Jelle de Wit, Yuri Souwer, Tineke Jorritsma, Hanny Klaasse Bos, Anja ten Brinke, Jacques Neefjes, S Marieke van Ham
Médium: Článek
Jazyk:English
Vydáno: Public Library of Science (PLoS) 2010-01-01
Edice:PLoS ONE
On-line přístup:http://europepmc.org/articles/PMC2946406?pdf=render