Enantioselective Benzylation and Allylation of α-Trifluoromethoxy Indanones under Phase-Transfer Catalysis

Enantioselective Benzylation and Allylation of α-Trifluoromethoxy Indanones under Phase-Transfer Catalysis

The organo-catalyzed enantioselective benzylation reaction of α-trifluoromethoxy indanones afforded α-benzyl-α-trifluoromethoxy indanones with a tetrasubstituted stereogenic carbon center in excellent yield with moderate enantioselectivity (up to 57% ee). Cinchona alkaloid...

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Bibliographic Details
Main Authors: Yumeng Liang, Mayaka Maeno, Zhengyu Zhao, Norio Shibata
Format: Article
Language:English
Published: MDPI AG 2019-07-01
Series:Molecules
Subjects:
trifluoromethoxy
fluorine
enantioselective
phase-transfer catalyst
organo-catalysis
Online Access:https://www.mdpi.com/1420-3049/24/15/2774

Internet

https://www.mdpi.com/1420-3049/24/15/2774

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