CaMK4 Promotes Acute Lung Injury Through NLRP3 Inflammasome Activation in Type II Alveolar Epithelial Cell

CaMK4 Promotes Acute Lung Injury Through NLRP3 Inflammasome Activation in Type II Alveolar Epithelial Cell

BackgroundType II alveolar epithelial cell (AEC II), in addition to its roles in maintaining lung homeostasis, takes an active role in inflammatory response during acute lung injury (ALI). Ca2+/calmodulin-dependent protein kinase IV (CaMK4) activated by Ca2+/calmodulin signaling, has been implicated...

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Bibliographic Details
Main Authors: Tengyue Zhang, Mengyuan Li, Siyuan Zhao, Mianjing Zhou, Huai Liao, Haiyan Wu, Xinyue Mo, Hongxing Wang, Chaohuan Guo, Hui Zhang, Niansheng Yang, Yuefang Huang
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-06-01
Series:Frontiers in Immunology
Subjects:
acute lung injury
CaMK4
type II alveolar epithelial cell
NLRP3 inflammasome
IL-1β
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.890710/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2022.890710/full

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