Inhibition of Arp2/3 Complex after ADP-Ribosylation of Arp2 by Binary <i>Clostridioides</i> Toxins

Inhibition of Arp2/3 Complex after ADP-Ribosylation of Arp2 by Binary <i>Clostridioides</i> Toxins

Clostridioides bacteria are responsible for life threatening infections. Here, we show that in addition to actin, the binary toxins CDT, C2I, and Iota from <i>Clostridioides difficile</i>, <i>botulinum</i>, and <i>perfrigens</i>, respectively, ADP-ribosylate the a...

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Bibliographic Details
Main Authors: Carsten Schwan, Alexander E. Lang, Andreas Schlosser, Setsuko Fujita-Becker, Abdulatif AlHaj, Rasmus R. Schröder, Jan Faix, Klaus Aktories, Hans Georg Mannherz
Format: Article
Language:English
Published: MDPI AG 2022-11-01
Series:Cells
Subjects:
actin
ADP-ribosyltransferases
Arp2/3 complex
<i>Clostridioides</i> binary toxins
Online Access:https://www.mdpi.com/2073-4409/11/22/3661

Internet

https://www.mdpi.com/2073-4409/11/22/3661

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