Pharmacologic TWIK‐Related Acid‐Sensitive K+ Channel (TASK‐1) Potassium Channel Inhibitor A293 Facilitates Acute Cardioversion of Paroxysmal Atrial Fibrillation in a Porcine Large Animal Model

Pharmacologic TWIK‐Related Acid‐Sensitive K+ Channel (TASK‐1) Potassium Channel Inhibitor A293 Facilitates Acute Cardioversion of Paroxysmal Atrial Fibrillation in a Porcine Large Animal Model

Background The tandem of P domains in a weak inward rectifying K+ channel (TWIK)‐related acid‐sensitive K+ channel (TASK‐1; hK2P3.1) two‐pore–domain potassium channel was recently shown to regulate the atrial action potential duration. In the human heart, TASK‐1 channels are specifically expressed i...

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Bibliographic Details
Main Authors: Felix Wiedmann, Christoph Beyersdorf, Xiaobo Zhou, Antonius Büscher, Manuel Kraft, Jendrik Nietfeld, Teo Puig Walz, Laura A. Unger, Axel Loewe, Bastian Schmack, Arjang Ruhparwar, Matthias Karck, Dierk Thomas, Martin Borggrefe, Gunnar Seemann, Hugo A. Katus, Constanze Schmidt
Format: Article
Language:English
Published: Wiley 2020-05-01
Series:Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Subjects:
A293
antiarrhythmic pharmacotherapy
atrial fibrillation
cardioversion
K2P3.1
TASK‐1
Online Access:https://www.ahajournals.org/doi/10.1161/JAHA.119.015751

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https://www.ahajournals.org/doi/10.1161/JAHA.119.015751

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