New Biologically Hybrid Pharmacophore Thiazolidinone-Based Indole Derivatives: Synthesis, In Vitro Αlpha-Amylase and Αlpha-Glucosidase Along with Molecular Docking Investigations

New Biologically Hybrid Pharmacophore Thiazolidinone-Based Indole Derivatives: Synthesis, In Vitro Αlpha-Amylase and Αlpha-Glucosidase Along with Molecular Docking Investigations

Amylase and glucosidase enzymes are the primary harmful source in the development of the chronic condition known as diabetes mellitus. The main function of these enzymes is to break the macromolecules into simple sugar units which are directly involved in the solubility of blood, hence increasing bl...

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Bibliographic Details
Main Authors: Shoaib Khan, Shahid Iqbal, Fazal Rahim, Mazloom Shah, Rafaqat Hussain, Hamad Alrbyawi, Wajid Rehman, Ayed A. Dera, Liaqat Rasheed, H. H. Somaily, Rami Adel Pashameah, Eman Alzahrani, Abd-ElAziem Farouk
Format: Article
Language:English
Published: MDPI AG 2022-10-01
Series:Molecules
Subjects:
synthesis
α-amylase
α-glucosidase enzymes
thiazolidinone
indole
SAR
Online Access:https://www.mdpi.com/1420-3049/27/19/6564

Internet

https://www.mdpi.com/1420-3049/27/19/6564

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