Ameliorating effects of ramelteon on oxidative stress, inflammation, apoptosis, and autophagy markers in methotrexate-induced cerebral toxicity

Ameliorating effects of ramelteon on oxidative stress, inflammation, apoptosis, and autophagy markers in methotrexate-induced cerebral toxicity

Objective(s): Methotrexate (MTX) is a widely used chemotherapeutic agent that, however, is known to have serious side effects such as neurotoxicity. In the present study, we aimed to evaluate the possible favorable effects of ramelteon (RMLT) on MTX-induced cerebral toxicity. Materials and Methods:...

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Bibliographic Details
Main Authors: Rahime Aslankoc, Mehtap Savran, Duygu Kumbul Doğuç, Murat Sevimli, Hale Tekin, Mine Kaynak
Format: Article
Language:English
Published: Mashhad University of Medical Sciences 2022-10-01
Series:Iranian Journal of Basic Medical Sciences
Subjects:
apoptosis
autophagy
cerebral toxicity
inflammation
methotrexate
oxidative stress
ramelteon
Online Access:https://ijbms.mums.ac.ir/article_21026_2d3eae5c3784152da3813b986dbb92cd.pdf

Internet

https://ijbms.mums.ac.ir/article_21026_2d3eae5c3784152da3813b986dbb92cd.pdf

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