Cooperative targeting of PARP-1 domains to regulate metabolic and developmental genes

Cooperative targeting of PARP-1 domains to regulate metabolic and developmental genes

PARP-1, also known as poly(ADP-ribose) polymerase 1, is a multifunctional nuclear enzyme that plays a critical role in transcriptional regulation through its three functional domains: the N-terminal DNA-binding domain (DBD) containing two zinc fingers for DNA binding and a third zinc finger for main...

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Bibliographic Details
Main Authors: Gbolahan Bamgbose, Sarah Johnson, Alexei Tulin
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-06-01
Series:Frontiers in Endocrinology
Subjects:
PARP-1
metabolic genes
developmental genes
gene expression
PARP-1 domains
Online Access:https://www.frontiersin.org/articles/10.3389/fendo.2023.1152570/full

Internet

https://www.frontiersin.org/articles/10.3389/fendo.2023.1152570/full

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