The bile salt deoxycholate induces Campylobacter jejuni genetic point mutations that promote increased antibiotic resistance and fitness

The bile salt deoxycholate induces Campylobacter jejuni genetic point mutations that promote increased antibiotic resistance and fitness

Oxidative damage to DNA is a significant source of mutations in living organisms. While DNA damage must be repaired to maintain the integrity of the genome and cell survival, errors made during DNA repair may contribute to evolution. Previous work has revealed that Campylobacter jejuni growth in the...

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Bibliographic Details
Main Authors: Prabhat K. Talukdar, Torin M. Crockett, Lisa M. Gloss, Steven Huynh, Steven A. Roberts, Kyrah L. Turner, Sebastien T. E. Lewis, Tristin L. Herup-Wheeler, Craig T. Parker, Michael E. Konkel
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-12-01
Series:Frontiers in Microbiology
Subjects:
sodium deoxycholate
reactive oxygen species
fluoroquinolone resistance
DNA lesions
DNA repair
Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2022.1062464/full

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https://www.frontiersin.org/articles/10.3389/fmicb.2022.1062464/full

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