Restoration of lysosomal acidification rescues autophagy and metabolic dysfunction in non-alcoholic fatty liver disease

Restoration of lysosomal acidification rescues autophagy and metabolic dysfunction in non-alcoholic fatty liver disease

Abstract Non-alcoholic fatty liver disease (NAFLD) is the most common liver disease in the world. High levels of free fatty acids in the liver impair hepatic lysosomal acidification and reduce autophagic flux. We investigate whether restoration of lysosomal function in NAFLD recovers autophagic flux...

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Main Authors: Jialiu Zeng, Rebeca Acin-Perez, Essam A. Assali, Andrew Martin, Alexandra J. Brownstein, Anton Petcherski, Lucía Fernández-del-Rio, Ruiqing Xiao, Chih Hung Lo, Michaël Shum, Marc Liesa, Xue Han, Orian S. Shirihai, Mark W. Grinstaff
Format: Article
Language:English
Published: Nature Portfolio 2023-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-023-38165-6

Internet

https://doi.org/10.1038/s41467-023-38165-6

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