Bispecific antibodies combine breadth, potency, and avidity of parental antibodies to neutralize sarbecoviruses

Bispecific antibodies combine breadth, potency, and avidity of parental antibodies to neutralize sarbecoviruses

Summary: SARS-CoV-2 variants evade current monoclonal antibody therapies. Bispecific antibodies (bsAbs) combine the specificities of two distinct antibodies taking advantage of the avidity and synergy provided by targeting different epitopes. Here we used controlled Fab-arm exchange to produce bsAbs...

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Bibliographic Details
Main Authors: Laura Radić, Kwinten Sliepen, Victor Yin, Mitch Brinkkemper, Joan Capella-Pujol, Angela I. Schriek, Jonathan L. Torres, Sandhya Bangaru, Judith A. Burger, Meliawati Poniman, Ilja Bontjer, Joey H. Bouhuijs, David Gideonse, Dirk Eggink, Andrew B. Ward, Albert J.R. Heck, Marit J. Van Gils, Rogier W. Sanders, Janke Schinkel
Format: Article
Language:English
Published: Elsevier 2023-04-01
Series:iScience
Subjects:
Immunology
Virology
Structural biology
Online Access:http://www.sciencedirect.com/science/article/pii/S258900422300617X

Internet

http://www.sciencedirect.com/science/article/pii/S258900422300617X

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