Bispecific antibodies combine breadth, potency, and avidity of parental antibodies to neutralize sarbecoviruses

Bispecific antibodies combine breadth, potency, and avidity of parental antibodies to neutralize sarbecoviruses

Summary: SARS-CoV-2 variants evade current monoclonal antibody therapies. Bispecific antibodies (bsAbs) combine the specificities of two distinct antibodies taking advantage of the avidity and synergy provided by targeting different epitopes. Here we used controlled Fab-arm exchange to produce bsAbs...

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Detaylı Bibliyografya
Asıl Yazarlar: Laura Radić, Kwinten Sliepen, Victor Yin, Mitch Brinkkemper, Joan Capella-Pujol, Angela I. Schriek, Jonathan L. Torres, Sandhya Bangaru, Judith A. Burger, Meliawati Poniman, Ilja Bontjer, Joey H. Bouhuijs, David Gideonse, Dirk Eggink, Andrew B. Ward, Albert J.R. Heck, Marit J. Van Gils, Rogier W. Sanders, Janke Schinkel
Materyal Türü: Makale
Dil:English
Baskı/Yayın Bilgisi: Elsevier 2023-04-01
Seri Bilgileri:iScience
Konular:
Immunology
Virology
Structural biology
Online Erişim:http://www.sciencedirect.com/science/article/pii/S258900422300617X

Internet

http://www.sciencedirect.com/science/article/pii/S258900422300617X

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