Importance of TRAIL Molecular Anatomy in Receptor Oligomerization and Signaling. Implications for Cancer Therapy

Importance of TRAIL Molecular Anatomy in Receptor Oligomerization and Signaling. Implications for Cancer Therapy

(TNF)-related apoptosis-inducing ligand (TRAIL) is able to activate the extrinsic apoptotic pathway upon binding to DR4/TRAIL-R1 and/or DR5/TRAIL-R2 receptors. Structural data indicate that TRAIL functions as a trimer that can engage three receptor molecules simultaneously, resulting in receptor tri...

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Bibliographic Details
Main Authors: Javier Naval, Diego de Miguel, Ana Gallego-Lleyda, Alberto Anel, Luis Martinez-Lostao
Format: Article
Language:English
Published: MDPI AG 2019-03-01
Series:Cancers
Subjects:
TRAIL
oligomerization
clusterization
cancer
immunotherapy
apoptosis
Online Access:https://www.mdpi.com/2072-6694/11/4/444

Internet

https://www.mdpi.com/2072-6694/11/4/444

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