SIRT7-Induced PHF5A Decrotonylation Regulates Aging Progress Through Alternative Splicing-Mediated Downregulation of CDK2

SIRT7-Induced PHF5A Decrotonylation Regulates Aging Progress Through Alternative Splicing-Mediated Downregulation of CDK2

Dysregulation of protein posttranslational modification (PTM) can lead to a variety of pathological processes, such as abnormal sperm development, malignant tumorigenesis, depression, and aging process. SIRT7 is a NAD+-dependent protein deacetylase. Besides known deacetylation, SIRT7 may also have t...

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Bibliographic Details
Main Authors: Ai Qing Yu, Jie Wang, Shi Tao Jiang, Li Qun Yuan, Hai Yan Ma, Yi Min Hu, Xing Min Han, Li Ming Tan, Zhi Xiao Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-09-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
Sirt7
PHF5A
crotonylation
cellular aging
alternative splicing
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.710479/full

Internet

https://www.frontiersin.org/articles/10.3389/fcell.2021.710479/full

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