Magnesium inhibits Wnt/β-catenin activity and reverses the osteogenic transformation of vascular smooth muscle cells.

Magnesium inhibits Wnt/β-catenin activity and reverses the osteogenic transformation of vascular smooth muscle cells.

Magnesium reduces vascular smooth muscle cell (VSMC) calcification in vitro but the mechanism has not been revealed so far. This work used only slightly increased magnesium levels and aimed at determining: a) whether inhibition of magnesium transport into the cell influences VSMC calcification, b) w...

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Bibliographic Details
Main Authors: Addy Montes de Oca, Fatima Guerrero, Julio M Martinez-Moreno, Juan A Madueño, Carmen Herencia, Alan Peralta, Yolanda Almaden, Ignacio Lopez, Escolastico Aguilera-Tejero, Kristina Gundlach, Janine Büchel, Mirjam E Peter, Jutta Passlick-Deetjen, Mariano Rodriguez, Juan R Muñoz-Castañeda
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3934896?pdf=render

Internet

http://europepmc.org/articles/PMC3934896?pdf=render

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