The repositioned drugs disulfiram/diethyldithiocarbamate combined to benznidazole: Searching for Chagas disease selective therapy, preventing toxicity and drug resistance

The repositioned drugs disulfiram/diethyldithiocarbamate combined to benznidazole: Searching for Chagas disease selective therapy, preventing toxicity and drug resistance

Chagas disease (CD) affects at least 6 million people in 21 South American countries besides several thousand in other nations all over the world. It is estimated that at least 14,000 people die every year of CD. Since vaccines are not available, chemotherapy remains of pivotal relevance. About 30%...

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Bibliographic Details
Main Authors: Juliana Almeida-Silva, Diego Silva Menezes, Juan Mateus Pereira Fernandes, Márcio Cerqueira Almeida, Deyvison Rhuan Vasco-dos-Santos, Roberto Magalhães Saraiva, Alessandra Lifsitch Viçosa, Sandra Aurora Chavez Perez, Sônia Gumes Andrade, Ana Márcia Suarez-Fontes, Marcos André Vannier-Santos
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-07-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
Trypanosoma cruzi
disulfiram
drug combination
repositioning
Chagas disease
chemotherapy
Online Access:https://www.frontiersin.org/articles/10.3389/fcimb.2022.926699/full

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https://www.frontiersin.org/articles/10.3389/fcimb.2022.926699/full

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