Epidermal Growth Factor Receptors in Vascular Endothelial Cells Contribute to Functional Hyperemia in the Brain

Epidermal Growth Factor Receptors in Vascular Endothelial Cells Contribute to Functional Hyperemia in the Brain

Functional hyperemia—activity-dependent increases in local blood perfusion—underlies the on-demand delivery of blood to regions of enhanced neuronal activity, a process that is crucial for brain health. Importantly, functional hyperemia deficits have been linked to multiple dementia risk factors, in...

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Bibliographic Details
Main Authors: Hannah R. Ferris, Nathan C. Stine, David C. Hill-Eubanks, Mark T. Nelson, George C. Wellman, Masayo Koide
Format: Article
Language:English
Published: MDPI AG 2023-11-01
Series:International Journal of Molecular Sciences
Subjects:
functional hyperemia
epidermal growth factor receptor (EGFR)
vascular endothelial cells
phosphatidylinositol 4,5-bisphosphate (PIP<sub>2</sub>)
cerebral small vessel diseases (cSVD)
Online Access:https://www.mdpi.com/1422-0067/24/22/16284

Internet

https://www.mdpi.com/1422-0067/24/22/16284

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