Testicular orphan receptor 4 induced hepatic stellate cells activation via the regulation of TGF-β receptor Ⅰ/Smad2/3 signaling pathway

Testicular orphan receptor 4 induced hepatic stellate cells activation via the regulation of TGF-β receptor Ⅰ/Smad2/3 signaling pathway

Introduction and Objectives: Liver fibrosis is a common pathological change in many chronic liver diseases. Activation of hepatic stellate cells (HSCs) is the core event in liver fibrosis. This study aimed to investigate the role of testicular orphan receptor 4 (TR4) in the activation of HSCs. Mater...

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Bibliographic Details
Main Authors: Yadong Fu, Yuping Zhou, Yongping Mu, Ying Lv, Gaofeng Chen, Hua Zhang, Ping Liu, Jiamei Chen
Format: Article
Language:English
Published: Elsevier 2023-01-01
Series:Annals of Hepatology
Subjects:
Hepatic stellate cells
Testicular orphan receptor 4
Retinoid X receptor α
TGF-β receptor Ⅰ/Smad2/3
Liver fibrosis
Online Access:http://www.sciencedirect.com/science/article/pii/S166526812200117X

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http://www.sciencedirect.com/science/article/pii/S166526812200117X

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