The Association of the COMT V158M Polymorphism with Endometrial/Ovarian Cancer in HNPCC Families Adhering to the Amsterdam Criteria

The Association of the COMT V158M Polymorphism with Endometrial/Ovarian Cancer in HNPCC Families Adhering to the Amsterdam Criteria

<p>Abstract</p> <p>Catechol-O-methyltransferase (COMT) is vital for the conjugation of catechol estrogens that are produced during oestrogen metabolism. The efficiency of this process varies due to a polymorphism in COMT, which changes valine to methionine (V158M). The Met genotype...

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Chi tiết về thư mục
Những tác giả chính: Ashton Katie A, Meldrum Cliff J, McPhillips Mary L, Suchy Janina, Kurzawski Grzegorz, Lubinski Jan, Scott Rodney J
Định dạng: Bài viết
Ngôn ngữ:English
Được phát hành: BMC 2006-05-01
Loạt:Hereditary Cancer in Clinical Practice
Những chủ đề:
HNPCC
colorectal cancer
endometrial cancer
COMT V158M
MMR
mutations
Truy cập trực tuyến:http://www.hccpjournal.com/content/4/2/94

Internet

http://www.hccpjournal.com/content/4/2/94

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