SUN-MKL1 Crosstalk Regulates Nuclear Deformation and Fast Motility of Breast Carcinoma Cells in Fibrillar ECM Microenvironment

SUN-MKL1 Crosstalk Regulates Nuclear Deformation and Fast Motility of Breast Carcinoma Cells in Fibrillar ECM Microenvironment

Aligned collagen fibers provide topography for the rapid migration of single tumor cells (streaming migration) to invade the surrounding stroma, move within tumor nests towards blood vessels to intravasate and form distant metastases. Mechanisms of tumor cell motility have been studied extensively i...

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Bibliographic Details
Main Authors: Ved P. Sharma, James Williams, Edison Leung, Joe Sanders, Robert Eddy, James Castracane, Maja H. Oktay, David Entenberg, John S. Condeelis
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:Cells
Subjects:
breast cancer invasion and metastasis
in vivo tumor cell motility
nuclear deformation
LINC complex
SRF-MKL1 signaling
Online Access:https://www.mdpi.com/2073-4409/10/6/1549

Internet

https://www.mdpi.com/2073-4409/10/6/1549

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