Obesity, but not high-fat diet, is associated with bone loss that is reversed via CD4+CD25+Foxp3+ Tregs-mediated gut microbiome of non-obese mice

Obesity, but not high-fat diet, is associated with bone loss that is reversed via CD4+CD25+Foxp3+ Tregs-mediated gut microbiome of non-obese mice

Abstract Osteoporosis is characterized by decreased bone mass, microarchitectural deterioration, and increased bone fragility. High-fat diet (HFD)-induced obesity also results in bone loss, which is associated with an imbalanced gut microbiome. However, whether HFD-induced obesity or HFD itself prom...

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Bibliographic Details
Main Authors: Wei Song, Qinglin Sheng, Yuying Bai, Li Li, Xin Ning, Yangeng Liu, Chen Song, Tianyi Wang, Xiaohua Dong, Yane Luo, Jinhong Hu, Lina Zhu, Xiaole Cui, Bing Chen, Lingling Li, Congli Cai, Haobo Cui, Tianli Yue
Format: Article
Language:English
Published: Nature Portfolio 2023-04-01
Series:npj Science of Food
Online Access:https://doi.org/10.1038/s41538-023-00190-6

Internet

https://doi.org/10.1038/s41538-023-00190-6

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