Similarities and Distinctions in Actions of Surface-Directed and Classic Androgen Receptor Antagonists.

Similarities and Distinctions in Actions of Surface-Directed and Classic Androgen Receptor Antagonists.

The androgen receptor (AR) surface-directed antagonist MJC13 inhibits AR function and proliferation of prostate cancer (PC) cells. These effects are related to arrest of an AR/chaperone complex in the cytoplasm. Here, we compared MJC13 and classic AR antagonists such as flutamide and bicalutamide. M...

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Bibliographic Details
Main Authors: Ji Ho Suh, Arundhati Chattopadhyay, Douglas H Sieglaff, Cheryl Storer Samaniego, Marc B Cox, Paul Webb
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4557941?pdf=render

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http://europepmc.org/articles/PMC4557941?pdf=render

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