FcγRIV is required for IgG2c mediated enhancement of RBC alloimmunization

FcγRIV is required for IgG2c mediated enhancement of RBC alloimmunization

Passive immunization with anti-D can prevent maternal alloimmunization to RhD thereby preventing hemolytic disease of the fetus and newborn. Unexpectedly, anti-D fails in some cases and some monoclonal anti-D preparations paradoxically enhances alloimmunization. The underlying mechanisms modulating...

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Bibliographic Details
Main Authors: Annie Qiu, Anabel Miller, Flavia Dei Zotti, Manjula Santhanakrishnan, Jeanne E. Hendrickson, Maria Tredicine, Sean R. Stowell, Chance John Luckey, James C. Zimring, Krystalyn E. Hudson
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-09-01
Series:Frontiers in Immunology
Subjects:
Fc receptor
antibody
red blood cell
alloantibody
antibody mediated enhancement
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.972723/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.972723/full

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